Symbol
Name
ID

Megf8
multiple EGF-like-domains 8
MGI:2446294

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal cardiovascular system morphology	Dextrocardia	Situs inversus totalis	Atrial septal defect	Ventricular septal defect	Tetralogy of Fallot	Transposition of the great arteries	Patent ductus arteriosus	Tricuspid regurgitation	Pulmonic stenosis	Polysplenia
Disease(s) Associated with MEGF8
Carpenter syndrome

Mouse Phenotypes

cardiovascular system phenotype

right aortic arch

coronary fistula

trabecula carnea hypoplasia

abnormal cardiac outflow tract development

abnormal direction of heart looping

absent coronary sinus

abnormal heart and great artery attachment

double outlet right ventricle

double outlet right ventricle, Taussig bing type

double outlet right ventricle, ventricular defect committed to aorta

transposition of great arteries

d-loop transposition of the great arteries

anomalous pulmonary venous connection

abnormal atrioventricular valve morphology

abnormal mitral valve morphology

abnormal tricuspid valve morphology

abnormal heart atrium morphology

right atrial isomerism

atrial septal defect

abnormal heart position or orientation

dextrocardia

mesocardia

abnormal heart septum morphology

atrioventricular septal defect

complete atrioventricular septal defect

muscular ventricular septal defect

ventricular septal defect

abnormal heart left ventricle morphology

heart right ventricle outflow tract stenosis

Availability

Mouse Genotype

Megf8^b2b288Clo/Megf8^b2b288Clo

Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo

Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst}

Megf8^hlb611/Megf8^hlb611

Megf8^tm1.1Ddg/Megf8^tm1.1Ddg

Megf8^tm1.2Ddg/Megf8^tm1.2Ddg
Mesp1^tm2(cre)Ysa/Mesp1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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